Diet Pills History

Introduction

The concept of beauty has changed over the years. Since the late 19^th century, the people’s perception and attitude towards weight has been constantly changing. This is true especially among women. The perception of weight has become slimmer through the years. Because of this change, researchers look for possible solutions that will effectively help them in weight loss. This was the birth of diet pills. Diet pills continued to evolve over time.

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Diet Pills in the Early Years

The very first diet pills were made available in the patent medicine era, which is in the late 1800s. The early diet pills are referred to as fat reducers. These were based on thyroid extract that increases the rate of metabolism. These pills were deemed to be an effective means to lose weight. However, the pills had their negative side effects. These would include increased heart rate, weakness, chest pains, hypertension, and death. Although the side effect s was significant, the pills were available until the 1960s.

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Early 20^th century

Dinitrophenol, a new medication, became a popular solution for weight loss in the 1930s. The drug is known to cause a thermogenic effect in the body. However, several accidental deaths due to hyperthermia caused by the drug occurred. There are other incidents such as severe rashes, problems in the sense of taste, and eye cataracts that were reported. These incidents led to the action of the Food and Drug Administration to control the usage of dinitrophenol in the United States of America.

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Mid of the 20^th Century

In 1950s amphetamines became popular. This drug was provided to soldiers during the World War II in order to keep them mentally alert. One of the known side effects of this drug was appetite suppression. Because of this effect, it was widely prescribed to promote weight loss. However, it comes with other risks such as addiction, neurological and psychological effects that were greater than the medical effect that it intends to do. On the other hand, another medication which was aminorex fumarate was introduced in 1965. This was developed to treat obesity but it causes pulmonary hypertension, causing it to be withdrawn in the market in 1968.

In 1960s, there was also resurgence in the use of thyroid hormones to promote weight loss. This is used in conjunction with other medications such as diuretics, amphetamines, and laxatives to promote weight loss. However, it was dropped immediately due to toxicity risks.

Rise of Ephedra

A Danish physician used ephedrine in combination with caffeine to treat asthma in the 1970s. Overtime, this treatment was used to treat weight loss. In the year 1994, the US passed the Dietary Supplement Health and Education Act and classified ephedra as an herb that doesn’t need the approval of FDA. As a result, the use of ephedra for the treatment of obesity increased. However, the adverse reactions caused by ephedra lead the FDA to declare it as an unsafe substance. Phenylpropanolamine, which is a derivative of ephedra, was also used to suppress the appetite but it causes hemorrhagic stroke and hypertension.

Fenfluramine

In 1973, Fenfluramine was approved to be used a weight loss treatment. The medication gained more popularity in 1992 when it was combined with phentermine. The combination of fenfluramine and phentermine was later known as fen-phen. In 1996, over 18,000,000 prescriptions were written. The adverse effects started to emerge among people who took fen-phen. These are heart lesions, pulmonary hypertension, and valve abnormalities. This combination drug was voluntarily removed from the market in 1997.
st Centurymost of the diet pills are based on herbal formulation. You can see lots of diet pills with herbal ingredients on them. Herbal formulation is relatively safer than chemical formulation.